Experimentally induced toxic-haemolytic anaemia in laboratory rats following phenacetin administration.

@article{Berger1985ExperimentallyIT,
  title={Experimentally induced toxic-haemolytic anaemia in laboratory rats following phenacetin administration.},
  author={Josef Berger},
  journal={Folia haematologica},
  year={1985},
  volume={112 4},
  pages={571-9}
}
In an attempt to give assistance in the search for a simple haematological system for the detection of toxic-haemolytic effects of chemical substances, we used a battery of simple tests and phenacetin as a reference substance. The drug was administered in a single dose or repeatedly for two or four weeks. Higher plasma haemoglobin levels and symptoms of anaemia (decreased blood haemoglobin levels, erythrocytic counts, haematocrit) and activated erythropoiesis (increased reticulocyte counts, MCV… CONTINUE READING