Experimentally-induced neuron loss in the locus coeruleus of adult rats.

  title={Experimentally-induced neuron loss in the locus coeruleus of adult rats.},
  author={Jean Marc Fritschy and Reinhard Grzanna},
  journal={Experimental neurology},
  volume={111 1},
Systemic administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) to adult rats causes widespread degeneration of locus coeruleus (LC) axon terminals. The present study was conducted to determine the effects of DSP-4-induced LC axon lesions on LC cell bodies. Six months after DSP-4 treatment, quantitative analysis of Nissl-stained sections revealed a profound loss of LC perikarya, ranging from 20 to 73% of control. The remaining LC neurons appeared… CONTINUE READING


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