Experimentally induced nasal irritation.

  title={Experimentally induced nasal irritation.},
  author={P Mohammadian and Dirk Schaefer and Thomas Hummel and Gerd Kobal},
  volume={37 4},
The aim of this study was to develop a method that is suited for the induction of nasal irritation. For this purpose inflammatory responses were analysed after challenging the nasal mucosa with experimentally induced cold, dry air (8 l/min, 22 degrees C, 20 %RH). To assess inflammatory effects we determined inflammatory mediators (prostaglandin E2 [PGE2], thromboxane B2 TXB2[, peptide leukotrienes pLT: LTC4, LTD4, LTE4[) in nasal lavage fluid which was sampled before, immediately after… CONTINUE READING