Experimentally-induced irritant contact dermatitis. Determination of optimum irritant concentrations.

@article{Willis1988ExperimentallyinducedIC,
  title={Experimentally-induced irritant contact dermatitis. Determination of optimum irritant concentrations.},
  author={Carolyn M. Willis and James Michael Stephens and J. D. Wilkinson},
  journal={Contact dermatitis},
  year={1988},
  volume={18 1},
  pages={
          20-4
        }
}
Patch testing with 7 irritants has been performed on a panel of 42 healthy volunteers, with the aim of determining concentrations which would induce mild to moderate reactions in at least 75% of individuals tested. The irritants studied and their optimum concentrations were as follows: benzalkonium chloride, 0.5%; sodium lauryl sulphate, 5%; croton oil, 0.8%; dithranol, 0.02%; nonanoic acid, 80%; propylene glycol, 100%; sodium hydroxide, 2%. Responder rates lower than 75% had to be accepted for… CONTINUE READING

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