Experimentally induced attenuation of neuropeptide-Y gene expression in transgenic mice increases mortality rate following seizures.

Previous experiments have reported increased seizure susceptibility in transgenic mice lacking normal neuropeptide-Y (NPY) gene expression (i.e. NPY 'knock-out' mice). A critical issue inherent in such experiments concerns the confounding of developmental influences of NPY and its neurotransmitter functions in the mature organism. The present experiments… CONTINUE READING