Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology.

@article{Britton2013ExperimentallyCP,
  title={Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology.},
  author={Oliver J. Britton and Alfonso Bueno-Orovio and Karel van Ammel and H. R. Lu and Robertson Towart and David J. Gallacher and B. Morales Rodriguez},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 23},
  pages={
          E2098-105
        }
}
Cellular and ionic causes of variability in the electrophysiological activity of hearts from individuals of the same species are unknown. However, improved understanding of this variability is key to enable prediction of the response of specific hearts to disease and therapies. Limitations of current mathematical modeling and experimental techniques hamper our ability to provide insight into variability. Here, we describe a methodology to unravel the ionic determinants of intersubject… CONTINUE READING

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