Experimental validation of measurements of glucose turnover in nonsteady state.

@article{Radziuk1978ExperimentalVO,
  title={Experimental validation of measurements of glucose turnover in nonsteady state.},
  author={Jerry M. Radziuk and Kenneth H. Norwich and Mladen Vranic},
  journal={The American journal of physiology},
  year={1978},
  volume={234 1},
  pages={E84-93}
}
The aim of the present experiments is to validate, in conscious dogs, the tracer infusion methods of measuring nonsteady turnover rates. This was done in nine experiments performed in four normal dogs by infusing isotopically labeled glucose (2-3H, 6-3H, 1-14C) and monitoring the concentrations of both the labeled and unlabeled substances. The validation is based on the observation that a high exogenous infusion of glucose will suppress endogenous glucose production and become the sole source… CONTINUE READING