Experimental tumors induced in rats by dichlorobenzidine

  • Gennady B Pliss
  • Published 1958 in Bulletin of Experimental Biology and Medicine


Prolonged administration of dichlorobenzidine, per os, or by injection into the subcutaneous connective tissue led to appearance of tumors in a substantial proportion of cases. Of the original number of 111 white rats, 64 survived to the appearance of the first tumor, and of these rats 30 had tumors of various types of locations, including 5 sarcomas at the injection site. It appears that both dichlorobenzidine and its metabolites possess cancerogenic activity in the rat.

DOI: 10.1007/BF00788073

Cite this paper

@article{Pliss1958ExperimentalTI, title={Experimental tumors induced in rats by dichlorobenzidine}, author={Gennady B Pliss}, journal={Bulletin of Experimental Biology and Medicine}, year={1958}, volume={46}, pages={1238-1240} }