Experimental treatments for human transmissible spongiform encephalopathies: is there a role for pentosan polysulfate?

  title={Experimental treatments for human transmissible spongiform encephalopathies: is there a role for pentosan polysulfate?},
  author={N. Rainov and Y. Tsuboi and P. Krolak-Salmon and A. Vighetto and K. Doh-Ura},
  journal={Expert Opinion on Biological Therapy},
  pages={713 - 726}
  • N. Rainov, Y. Tsuboi, +2 authors K. Doh-Ura
  • Published 2007
  • Medicine
  • Expert Opinion on Biological Therapy
  • Human transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are caused by the accumulation of an abnormal isoform of the prion protein in the CNS. Creutzfeldt-Jakob disease in its sporadic form is the most frequent type of human TSE. At present, there is no proven specific or effective treatment available for any form of TSE. Pentosan polysulfate (PPS) has been shown to prolong the incubation period when administered to the cerebral ventricles in a rodent TSE model… CONTINUE READING
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