Experimental transmission of h-type bovine spongiform encephalopathy to bovinized transgenic mice.

@article{Okada2011ExperimentalTO,
  title={Experimental transmission of h-type bovine spongiform encephalopathy to bovinized transgenic mice.},
  author={Hiroyuki Okada and Kentaro Masujin and Yoshihumi Iwamaru and Morikazu Imamura and Yuichi Matsuura and Shirou Mohri and Stefanie Czub and Takashi Yokoyama},
  journal={Veterinary pathology},
  year={2011},
  volume={48 5},
  pages={942-7}
}
To characterize the biological and biochemical properties of H-type bovine spongiform encephalopathy (BSE), a transmission study with a Canadian H-type isolate was performed with bovinized transgenic mice (TgBoPrP), which were inoculated intracerebrally with brain homogenate from cattle with H-type BSE. All mice exhibited characteristic neurologic signs, and the subsequent passage showed a shortened incubation period. The distribution of disease-associated prion protein (PrP(Sc)) was determined… CONTINUE READING
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  • AG Biacabe, JL Laplanche, S Ryder, T Baron
  • 2007

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