Experimental therapy of prostate cancer with an immunomodulatory oligonucleotide: effects on tumor growth, apoptosis, proliferation, and potentiation of chemotherapy.

@article{Rayburn2006ExperimentalTO,
  title={Experimental therapy of prostate cancer with an immunomodulatory oligonucleotide: effects on tumor growth, apoptosis, proliferation, and potentiation of chemotherapy.},
  author={Elizabeth R. Rayburn and Wei Wang and Zhuo Zhang and Mengting Li and Ruiwen Zhang and Hui Wang},
  journal={The Prostate},
  year={2006},
  volume={66 15},
  pages={
          1653-63
        }
}
BACKGROUND The present study was designed to demonstrate the therapeutic efficacy of a novel immunomodulatory oligonucleotide (IMO) for prostate cancer. METHODS We evaluated the effects of the IMO in xenograft (PC-3) and syngeneic (TRAMP C1) models of prostate cancer, and in prostate cancer cells. The IMO was also evaluated in combination with chemotherapy, and the in vitro expression of TLR9 was examined. RESULTS The IMO had significant anti-tumor activity in both prostate cancer models… CONTINUE READING

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