• DOI:10.1038/nrn1386
Corpus ID: 19496441

Experimental therapeutics in transgenic mouse models of Huntington's disease

@article{Beal2004ExperimentalTI,
  title={Experimental therapeutics in transgenic mouse models of Huntington's disease},
  author={M. F. Beal and R. Ferrante},
  journal={Nature Reviews Neuroscience},
  year={2004},
  volume={5},
  pages={373-384}
}

M. F. Beal, R. Ferrante

Published 2004

Biology, Medicine

Nature Reviews Neuroscience

Despite important advances in understanding and elucidating the molecular and mechanistic pathways that mediate progression in Huntington's disease (HD), effective pharmacotherapy remains elusive. Insights into disease pathogenesis have come from studies using tissue culture, yeast, Caenorhabditis elegans, Drosophila melanogaster and transgenic mouse models. Here, we present a brief overview of HD pathogenesis and discuss the efficacy of therapeutic agents in transgenic mouse models of HD. We… CONTINUE READING

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