Experimental therapeutics in transgenic mouse models of Huntington's disease

  title={Experimental therapeutics in transgenic mouse models of Huntington's disease},
  author={M. F. Beal and R. Ferrante},
  journal={Nature Reviews Neuroscience},
  • M. F. Beal, R. Ferrante
  • Published 2004
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • Despite important advances in understanding and elucidating the molecular and mechanistic pathways that mediate progression in Huntington's disease (HD), effective pharmacotherapy remains elusive. Insights into disease pathogenesis have come from studies using tissue culture, yeast, Caenorhabditis elegans, Drosophila melanogaster and transgenic mouse models. Here, we present a brief overview of HD pathogenesis and discuss the efficacy of therapeutic agents in transgenic mouse models of HD. We… CONTINUE READING
    210 Citations

    Figures, Tables, and Topics from this paper

    Paper Mentions

    Interventional Clinical Trial
    The goals of this trial are to determine if coenzyme Q10 is effective in slowing the worsening symptoms of Huntington's disease and to learn about the safety and acceptability of… Expand
    ConditionsHuntington's Disease
    InterventionDrug, Other
    Mouse models of Huntington's disease and methodological considerations for therapeutic trials.
    • R. Ferrante
    • Biology, Medicine
    • Biochimica et biophysica acta
    • 2009
    • 127
    Experimental models of HD and reflection on therapeutic strategies.
    • 25
    Lessons Learned from the Transgenic Huntington's Disease Rats
    • 12
    • PDF
    Emerging chemotherapeutic strategies for Huntington’s disease
    • 30
    Huntington's disease: progress and potential in the field
    • 41
    RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.
    • 627
    • PDF
    Huntington ’ s disease : progress and potential in the fi eld
    • 1
    • PDF


    Transgenic rat model of Huntington's disease.
    • 327
    • PDF
    Neurological abnormalities in a knock-in mouse model of Huntington's disease.
    • 550
    • PDF
    Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease
    • 516
    • PDF