Experimental techniques for study of chromatin mechanics in intact nuclei and living cells

@article{Verstraeten2008ExperimentalTF,
  title={Experimental techniques for study of chromatin mechanics in intact nuclei and living cells},
  author={Valerie L. R. M. Verstraeten and Jan Lammerding},
  journal={Chromosome Research},
  year={2008},
  volume={16},
  pages={499-510}
}
While the structure of chromatin and its physical properties have been well studied on isolated chromatin fibres and DNA strands in vitro, its organization and function in the intact interphase nucleus is less clear. Chromatin organization is critical for transcriptional regulation and DNA replication, and mounting evidence suggests that cells respond to changes in the mechanical environment with alterations in nuclear architecture that are accompanied by modifications in gene expression. Since… CONTINUE READING

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