Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration.

@article{Masubuchi2013ExperimentalST,
  title={Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration.},
  author={Takahiro Masubuchi and Y Kajimoto and Shinji Kawabata and Naosuke Nonoguchi and Takahiro Fujishiro and Shin-ichi Miyatake and Toshihiko Kuroiwa},
  journal={Photomedicine and laser surgery},
  year={2013},
  volume={31 9},
  pages={428-33}
}
OBJECTIVE (PpIX) fluorescence induced by 5-aminolevulinic acid (5-ALA), which appears in various tumors including malignant gliomas, is a good navigator for tumor resection. However, some non-neoplastic tissue also shows a weak PpIX fluorescence. The origin of non-neoplastic PpIX is still unknown, and three hypotheses on its origins can be proposed: tumor cell-derived PpIX followed by dispersal via bulk flow, direct PpIX production by normal brain or gliotic brain tissue, or PpIX produced in… CONTINUE READING