Experimental study on thermal damage to dog normal brain.

  title={Experimental study on thermal damage to dog normal brain.},
  author={Noriaki Ikeda and O Hayashida and Haruo Kameda and Hiroshi Ito and Tadayoshi Matsuda},
  journal={International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group},
  volume={10 4},
We investigated the temperature changes and their distribution in agar phantoms and dog normal brains induced by 8 MHz radiofrequency interstitial hyperthermia and observed the histological changes, with respect to the neurons and myelinated nerve fibres, induced by the same heat source in dog normal brains. We also examined the change of blood-brain barrier permeability using Evans blue solution. The heating limits of dog normal brain were 42 degrees C for 45 min or 43 degrees C for 15 min and… CONTINUE READING
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