• DOI:10.3928/01477447-20110714-07
• Corpus ID: 29439025

Experimental study on phase-contrast imaging with synchrotron hard X-ray for repairing osteonecrosis of the femoral head.

@article{Sun2011ExperimentalSO,
  title={Experimental study on phase-contrast imaging with synchrotron hard X-ray for repairing osteonecrosis of the femoral head.},
  author={Wei Sun and Zirong Li and Yu-run Yang and Zhengcai Shi and Bailiang Wang and Bing-li Liu and Shao-hui Shi},
  journal={Orthopedics},
  year={2011},
  volume={34 9},
  pages={
          e530-4
        }
}

• Wei Sun, Zirong Li, +4 authors Shao-hui Shi
• Published 9 September 2011
• Physics
• Orthopedics

Synchrotron radiation light is 1 of 4 artificial light sources, the others being electric light, X-ray, and laser. Phase-contrast imaging with hard X-ray has achieved wide application in many scientific fields, such as biomedicine and material science. This article compares the effectiveness of nanohydroxyapatite/collagen (nHAC) and autologous mesenchymal stem cell for the repair of defects in a rabbit model with osteonecrosis of the femoral head under the monitoring of phase-contrast imaging with synchrotron hard X-ray. We established models of bilateral osteonecrosis of the femoral head defect using New Zealand rabbits and divided them into 3 groups. Imaging techniques such as phase-contrast imaging and diffraction enhanced imaging with synchrotron hard X-ray were applied to assess the degradation and repair process of nHAC and mesenchymal stem cell at 4, 8, and 12 weeks postoperatively. We found phase-contrast imaging with synchrotron hard X-ray displayed the reparative process of the bone defect, degradation of nHAC, and osteocyte substitution. There were significant differences in the repair of the bone defect and osteogenesis in groups B and C compared with group A (control). Osteogenesis was more significant in group C. We provided experimental data for the development and application of synchrotron hard X-ray imaging techniques and concluded that phase-contrast microimaging with synchrotron hard X-ray displays the reparative process of bone tissue at a micro-level and plays an important role in the development of tissue engineering.