Experimental study on apoptosis of HL-60 cell induced by arsenic trioxide.

Abstract

OBJECTIVE To explore the mechanism of arsenic (arsenic trioxide, AS2O3) in treating leukemia. METHODS The in vitro effect of arsenic trioxide on HL-60 model double-labelled with PI/AnnexinV-FITC was studied ith flow cytometry. Function on telomerase activity was also observed. RESULTS After the effect of arsenic on HL-60 cell line, PI negative/AnnexinV… (More)

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