Experimental study of the effects of Optison concentration on sonoporation in vitro.

@article{Ward2000ExperimentalSO,
  title={Experimental study of the effects of Optison concentration on sonoporation in vitro.},
  author={Matthew Ward and Junru Wu and J. F. Chiu},
  journal={Ultrasound in medicine & biology},
  year={2000},
  volume={26 7},
  pages={1169-75}
}
Lethal sonoporation and reparable sonoporation were observed in Jurkat lymphocytes in suspension with the addition of varying amounts of Optison, a commercially available bubble-based contrast agent. For given ultrasound (US) exposure conditions (spatial peak-pressure amplitude of 0.2 MPa, duty cycle 10% and 2-MHz frequency), sonoporation was directly related to the bubble-to-cell ratio (in a range from 0 to 230). It was found that the nearest bubble-cell spacing was also related to the… CONTINUE READING

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