Experimental study of determinants of aneurysmal expansion of the abdominal aorta.

@article{Anidjar1994ExperimentalSO,
  title={Experimental study of determinants of aneurysmal expansion of the abdominal aorta.},
  author={S Anidjar and Philip B. Dobrin and Gregorio Chejfec and J B Michel},
  journal={Annals of vascular surgery},
  year={1994},
  volume={8 2},
  pages={127-36}
}
The natural history and the factors determining the expansion of aneurysms have not been elucidated. To study the respective roles of elastolysis, collagenolysis, inflammatory cells, and hypertension in the pathogenesis of aneurysms, two previously described in vivo experimental models were used. An isolated segment of the abdominal aorta was infused with 15 units of pancreatic elastase. The maximal diameter of the aorta was measured before and after infusion and the isolated aorta was excised… CONTINUE READING