Experimental study of a novel phospholipase A2 inhibitor in acute pancreatitis.

Abstract

BACKGROUND In acute pancreatitis, two different types of secretory phospholipase A2 (PLA2) have been found: pancreatic type I PLA2 and non-pancreatic type II PLA2. In this study a potent new PLA2 inhibitor effective against type II PLA2 was used in an experimental model of acute pancreatitis. METHODS In 70 rats the efficacy of the compound was analysed in… (More)

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