Experimental studies on the pathogenesis and prophylaxis of stroke in stroke-prone spontaneously hypertensive rats (SHR).(1) Quantitative estimation of cerebrovascular permeability.

@article{Yamori1975ExperimentalSO,
  title={Experimental studies on the pathogenesis and prophylaxis of stroke in stroke-prone spontaneously hypertensive rats (SHR).(1) Quantitative estimation of cerebrovascular permeability.},
  author={Yukio Yamori and Ryoichi Horie and Motohiko Sato and Shin-ichi Sasagawa and Kozo Okamoto},
  journal={Japanese circulation journal},
  year={1975},
  volume={39 5},
  pages={611-5}
}
The cerebrovascular permeability quantitatively determined by the retention of 131I-human albumin in the perfused brains was increased in SHR, especially in stroke-prone SHR compared with normotensive Wistar-Kyoto, and confirmed the macroscopical or microscopical findings on the leakage into the brain or trypan blue or peroxidase injected intravenously 2 to 3 hours before sacrifice. The localization of increased vascular permeability in SHR corresponded to the predilection sites of cerebral… CONTINUE READING

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