Experimental studies on the antitumor effect of ethidium bromide and related substances.

Abstract

The antileukemic activity of ethidium bromide, an inhibitor of RNA-dependent DNA polymerase activity, and of 14 related agents newly synthesized was tested in experimental tumor systems. Ethidium bromide caused up to 200% increased life-span in mice with 6C3HED-OG and 83% increased life-span in mice with L5178Y. No substantial percentage of increased life… (More)

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