Experimental studies on cortisol-induced hypertension in humans.

  title={Experimental studies on cortisol-induced hypertension in humans.},
  author={Judith Ann Whitworth and Mark Ashley Brown and John P. J. Kelly and Paula M. Williamson},
  journal={Journal of human hypertension},
  volume={9 6},
Studies in humans have shown that cortisol administration (200 mg/day) increases cardiac output, renal vascular resistance, glomerular filtration rate, plasma volume, extracellular fluid volume, exchangeable sodium, plasma glucose, insulin, renin substrate and atrial natriuretic peptide concentrations as well as urinary kallikrein excretion. Cortisol treatment decreases renin and angiotensin II concentrations while catecholamines and vasopressin are decreased or unchanged. We have clear… CONTINUE READING