• Corpus ID: 20550382

Experimental studies in vitro and in vivo on the mutagenicity of flavoxate.

@article{Veronese1987ExperimentalSI,
  title={Experimental studies in vitro and in vivo on the mutagenicity of flavoxate.},
  author={Maria Veronese and Dagania Barzaghi},
  journal={Arzneimittel-Forschung},
  year={1987},
  volume={37 5},
  pages={
          528-31
        }
}
Flavoxate HCl is a drug with a remarkable smooth muscle relaxant activity, selective for the genito-urinary tract. In order to verify its safety the following mutagenic tests have been effected: gene reversion in S. typhimurium, gene conversion and crossing-over on S. cerevisiae 6117, micronucleus test and DNA-repair on B. subtilis. In our experimental conditions, flavoxate HCl was found to be devoid of potential mutagenic activity. 
2 Citations
A Review of Flavoxate Hydrochloride in the Treatment of Urge Incontinence
  • R. Ruffmann
  • Medicine
    The Journal of international medical research
  • 1988
TLDR
Recent evidence indicates that flavoxate hydrochloride exhibits only weak anticholinergic activity on receptors involved in the control of the lower urinary tract.