Experimental strategies to promote central nervous system remyelination in multiple sclerosis: insights gained from the Theiler's virus model system.

@article{Miller1995ExperimentalST,
  title={Experimental strategies to promote central nervous system remyelination in multiple sclerosis: insights gained from the Theiler's virus model system.},
  author={D J Miller and Kunihiko Asakura and Moses Rodriguez},
  journal={Journal of neuroscience research},
  year={1995},
  volume={41 3},
  pages={291-6}
}
The destruction of central nervous system (CNS) myelin, the lipid-rich insulator surrounding axons in the mammalian brain and spinal cord, is the primary pathological finding in multiple sclerosis. Myelin loss can result in a significant clinical deficit, and was originally thought to be permanent, similar to axonal destruction. However, myelin regeneration is now an established phenomenon in both human disease and animal models of CNS demyelination. In this review, the concept of remyelination… CONTINUE READING