Experimental status epilepticus alters gamma-aminobutyric acid type A receptor function in CA1 pyramidal neurons.

@article{Kapur1995ExperimentalSE,
  title={Experimental status epilepticus alters gamma-aminobutyric acid type A receptor function in CA1 pyramidal neurons.},
  author={Jaideep Kapur and Douglas A. Coulter},
  journal={Annals of neurology},
  year={1995},
  volume={38 6},
  pages={893-900}
}
There is a reduction of gamma-aminobutyric acid (GABA)-mediated inhibition of the CA1 pyramidal region of the hippocampus during status epilepticus (SE). The cellular basis of this loss of GABA-mediated inhibition is not known. This study tested the possibility that GABA type A (GABAA) receptor function in CA1 pyramidal neurons was reduced or blocked during SE, at least in part by postsynaptic cellular mechanisms. GABAA receptor currents (IGABA) were studied by whole-cell patch-clamp techniques… CONTINUE READING
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