Experimental silicosis. II. Long-term effects of intratracheally instilled quartz on collagen metabolism and morphologic characteristics of rat lungs.

Abstract

Rats received intratracheal instillations of 50 mg of silica (quartz, 0.5 mu particles). One, 2, 4, 5, 6, 9, and 12 months later, the lungs were evaluated histologically and by various biochemical measurements. The lung content of protein, proline, and hydroxyproline (collagen) were quantitated, as were the synthesis rates of lung collagen and the total… (More)

Topics

Cite this paper

@article{Reiser1983ExperimentalSI, title={Experimental silicosis. II. Long-term effects of intratracheally instilled quartz on collagen metabolism and morphologic characteristics of rat lungs.}, author={K. M. Reiser and Wanda M. Haschek and T W Hesterberg and James Last}, journal={The American journal of pathology}, year={1983}, volume={110 1}, pages={30-40} }