Experimental short-term fetal bladder outflow obstruction: I. Morphology and cell biology associated with urinary flow impairment.

@article{Farrugia2006ExperimentalSF,
  title={Experimental short-term fetal bladder outflow obstruction: I. Morphology and cell biology associated with urinary flow impairment.},
  author={M K Farrugia and David A Long and Margaret L. Godley and Donald Peebles and Christopher H Fry and Peter M. Cuckow and Adrian S Woolf},
  journal={Journal of pediatric urology},
  year={2006},
  volume={2 4},
  pages={
          243-53
        }
}
PURPOSE In fetal sheep, combined urethral and urachal obstruction initiated at 75 days' gestation and maintained for 30 days led to dysmorphic bladders, similar to those found in humans with prune belly syndrome, and uniformly disrupted kidney development. We aimed to create a less severe model of fetal bladder outlet obstruction, more closely resembling infants with posterior urethral valves, and additionally to further our understanding on the role of the urachus. We hypothesized that milder… CONTINUE READING