Experimental scrapie in mice: ultrastructural observations.

  title={Experimental scrapie in mice: ultrastructural observations.},
  author={J. Richard Baringer and Stanley B Prusiner},
  journal={Annals of neurology},
  volume={4 3},
Scrapie, kuru, and Creutzfeldt-Jakob disease are characterized by a similar spongiform pathology, prolonged incubation periods, and an agent with unique physical, chemical, and biological properties. Swiss mice were inoculated with the scrapie agent and sacrificed three to five months later for light and electron microscopy. At three months, small vacuoles were seen within the neuropil of the cerebral cortex and basal ganglia. By the fifth month these vacuoles had increased in number and size… CONTINUE READING