Experimental rhinovirus infection increases human tissue kallikrein activation in allergic subjects.

@article{Christiansen2008ExperimentalRI,
  title={Experimental rhinovirus infection increases human tissue kallikrein activation in allergic subjects.},
  author={Sandra C. Christiansen and Jane M Eddleston and Sara H Bengtson and G. Ronald Jenkins and Robert B Sarnoff and Ronald B. Turner and Jack M. Gwaltney and Bruce L Zuraw},
  journal={International archives of allergy and immunology},
  year={2008},
  volume={147 4},
  pages={
          299-304
        }
}
BACKGROUND Rhinovirus infection is a major cause of asthma exacerbations. While rhinovirus infection is known to generate kinins in the upper respiratory track, little is known about the effect of rhinovirus on kinin generation in the lower airway. We previously identified human tissue kallikrein (hTK) as the principal lung kininogenase during allergic airway inflammation. In this report we investigate the effect of experimental rhinovirus infection on hTK activity in the airways of atopic… CONTINUE READING