Experimental radioimmunotherapy of a xenografted human glioma using 131I-labeled monoclonal antibody to epidermal growth factor receptor.

@article{Takahashi1993ExperimentalRO,
  title={Experimental radioimmunotherapy of a xenografted human glioma using 131I-labeled monoclonal antibody to epidermal growth factor receptor.},
  author={Hidemi Takahashi and Shozo Nakazawa and Dorothee M Herlyn},
  journal={Neurologia medico-chirurgica},
  year={1993},
  volume={33 9},
  pages={610-5}
}
131I-labeled F(ab')2 fragments of murine monoclonal antibody (MAb) 425 specific to the epidermal growth factor receptor expressed on human gliomas were used in experimental human malignant glioma immunotherapy. Two injections of 150 microCi 131I-labeled 425 F(ab')2 achieved growth inhibition of U-87MG human malignant glioma xenografts in nude mice. This… CONTINUE READING