Experimental production of nutritional macrocytic anemia in swine. V. Hematologic manifestations of a combined deficiency of vitamin B12 and pteroylglutamic acid.

@article{Cartwright1952ExperimentalPO,
  title={Experimental production of nutritional macrocytic anemia in swine. V. Hematologic manifestations of a combined deficiency of vitamin B12 and pteroylglutamic acid.},
  author={G. Cartwright and B. Tatting and D. Kurth and M. Wintrobe},
  journal={Blood},
  year={1952},
  volume={7 10},
  pages={
          992-1004
        }
}
  • G. Cartwright, B. Tatting, +1 author M. Wintrobe
  • Published 1952
  • Medicine
  • Blood
  • A total of 20 swine were fed a diet adequate in all known respects except that soybean protein was substituted for casein, succinylsulfathiazole and a folic acid antagonist were added, and vitamin B12 and pteroylglutamic acid were withheld from the vitamin supplement. The animals developed macrocytic anemia, leukopenia and neutropenia, accompanied by erythroid hyperplasia of the bone marrow. Tue erythroblasts consisted mainly of immature macronormoblasts but a few atypical megaloblasts were… CONTINUE READING
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