• Corpus ID: 19056216

Experimental production of carcinoma with cigarette tar.

@article{Wynder1953ExperimentalPO,
  title={Experimental production of carcinoma with cigarette tar.},
  author={Ernest L. Wynder and Evarts A. Graham and A B Croninger},
  journal={Cancer research},
  year={1953},
  volume={13 12},
  pages={
          855-64
        }
}
1. A cigarette tar condensate was obtained with a smoking machine which simulated human smoking habits. The resulting tar was dissolved in acetone and applied to the backs of CAF1 mice in a dosage of 40 mg. of tar/acetone solution 3 times a week. Control mice were painted with acetone. 2. Of 81 tarred mice, 59 per cent developed papillomas. The first lesion was noted in the 33d week, and the mean time of appearance was 56 weeks. 3. Of 81 tarred mice, 44 per cent developed histologically… 

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  • 1965
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