Experimental poststreptococcal glomerulonephritis elicited by IgG Fc-binding M family proteins and blocked by IgG Fc fragment.

@article{Burova2012ExperimentalPG,
  title={Experimental poststreptococcal glomerulonephritis elicited by IgG Fc-binding M family proteins and blocked by IgG Fc fragment.},
  author={Larissa Burova and Peter Pigarevsky and Valentina Seliverstova and Tatiana Gupalova and Claes Schal{\'e}n and Artem A. Totolian},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  year={2012},
  volume={120 3},
  pages={221-30}
}
The pathogenesis of acute poststreptococcal glomerulonephritis (APSGN), a major nonsuppurative complication of group A streptococcal (GAS) throat or skin disease, remains unclear. During the years, various theories based on certain streptococcal extracellular factors, as well as immunological mimicry between streptococci and renal tissue, have been forwarded. We earlier reported that many clinical GAS isolates with documented nephritogenic capacity show non-immune binding of monomeric or… CONTINUE READING