Experimental parameters differentially affect the humoral response of the cholera-toxin-based murine model of food allergy.

@article{Kroghsbo2003ExperimentalPD,
  title={Experimental parameters differentially affect the humoral response of the cholera-toxin-based murine model of food allergy.},
  author={Stine Kroghsbo and Hanne Risager Christensen and Hanne Fr\okiaer},
  journal={International archives of allergy and immunology},
  year={2003},
  volume={131 4},
  pages={256-63}
}
BACKGROUND Recent studies have developed a murine model of IgE-mediated food allergy based on oral coadministration of antigen and cholera toxin (CT) to establish a maximal response for studying immunopathogenic mechanisms and immunotherapeutic strategies. However, for studying subtle immunomodulating factors or factors effective during response initiation, this maximal response-based model is less suitable due to a lack of sensitivity. Therefore, in attempts to identify essential parameters to… CONTINUE READING