Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen.

@article{Walker1998ExperimentalPI,
  title={Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen.},
  author={Judith S. Walker and John Carmody},
  journal={Anesthesia and analgesia},
  year={1998},
  volume={86 6},
  pages={1257-62}
}
UNLABELLED We used electrically induced pain in healthy young subjects to study gender differences in nociception and the analgesic efficacy of ibuprofen. Cutaneous stimulation of the earlobe allowed measurement of pain detection thresholds and maximal pain tolerance. Drug and placebo were each administered twice using a double-blind, randomized, multiple cross-over design. Male subjects had greater stimulus thresholds (lower nociception) compared with female subjects (18 +/- 0.3 vs 15 +/- 0.3… CONTINUE READING

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