Experimental osteonecrosis: development of a model in rodents administered alendronate.

@article{Conte2016ExperimentalOD,
  title={Experimental osteonecrosis: development of a model in rodents administered alendronate.},
  author={Nicolau Conte and Lu{\'i}s Carlos Spolid{\'o}rio and Cl{\'e}verton Roberto de Andrade and J{\^o}natas Caldeira Esteves and Elcio Marcantonio},
  journal={Brazilian oral research},
  year={2016},
  volume={30 1},
  pages={
          e99
        }
}
The main objective of this study was to cause bisphosphonate-related osteonecrosis of the jaws to develop in a rodent model. Adult male Holtzman rats were assigned to one of two experimental groups to receive alendronate (AL; 1 mg/kg/week; n = 6) or saline solution (CTL; n = 6). After 60 days of drug therapy, all animals were subjected to first lower molar extraction, and 28 days later, animals were euthanized. All rats treated with alendronate developed osteonecrosis, presenting as ulcers and… CONTINUE READING

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