Experimental oral cancer in rats with xerostomia.

Though previous experiments with fat-soluble carcinogens have demonstrated a protective effect of the saliva against chemically induced oral cancer it is not known if this also holds true for water-soluble carcinogenic agents. In vitro experiments indicate that the water-soluble 4NQO (4-nitrochinoline N-oxide) easily penetrates a layer of saliva similar… CONTINUE READING