Experimental oesophagitis in the rat is associated with decreased voluntary movement.

@article{Miwa2009ExperimentalOI,
  title={Experimental oesophagitis in the rat is associated with decreased voluntary movement.},
  author={Hiroto Miwa and Tadayuki Oshima and Jun Sakurai and Toshihiko Tomita and Takeshi Matsumoto and Seiichi Iizuka and Junichi Koseki},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2009},
  volume={21 3},
  pages={296-303}
}
Growing interest has arisen regarding the mechanism of dyspeptic symptom generation. However, no evaluation system of these symptoms in animals has been developed. In this study, we examined whether voluntary movement of rats could be a measure to assess visceral symptoms of reflux oesophagitis. A chronic acid reflux oesophagitis model was made using rats, and the size of erosions was measured. Omeprazole was administered to the oesophagitis rats for 10 days. The amount of voluntary movement… CONTINUE READING