Experimental obstructive jaundice disrupts intestinal mucosal barrier by altering occludin expression: beneficial effect of bombesin and neurotensin.

@article{Assimakopoulos2004ExperimentalOJ,
  title={Experimental obstructive jaundice disrupts intestinal mucosal barrier by altering occludin expression: beneficial effect of bombesin and neurotensin.},
  author={Stelios F. Assimakopoulos and Chrisoula D. Scopa and Aristides S Charonis and Iris Spiliopoulou and Christos D. Georgiou and Vassiliki N. Nikolopoulou and Constantine E. Vagianos},
  journal={Journal of the American College of Surgeons},
  year={2004},
  volume={198 5},
  pages={748-57}
}
BACKGROUND Little is known of the molecular events leading to increased intestinal permeability in obstructive jaundice. This study was undertaken to investigate the influence of experimental obstructive jaundice on the expression of the tight junction-associated protein occludin in the intestinal epithelium. STUDY DESIGN Seventy male Wistar rats were randomly divided into five groups: I, controls; II, sham-operated; III, bile duct ligation (BDL); IV, BDL+Bombesin (BBS) (30 microg/kg/d); and… CONTINUE READING
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