Experimental neuropathy in mice is associated with delayed behavioral changes related to anxiety and depression.

@article{Suzuki2007ExperimentalNI,
  title={Experimental neuropathy in mice is associated with delayed behavioral changes related to anxiety and depression.},
  author={Takahiro Suzuki and Mitsuyuki Amata and Gaku Sakaue and Shinya Nishimura and Shunsuke Inoue and Masahiko Shibata and Takashi Mashimo},
  journal={Anesthesia and analgesia},
  year={2007},
  volume={104 6},
  pages={
          1570-7, table of contents
        }
}
BACKGROUND Patients with chronic pain frequently suffer affective disorders, particularly anxiety and depression. Although clinical research on the relationship between pain and depressive symptoms has been done, it is not clear whether pain causes depression or depression exaggerates pain. To investigate the relation between pain and affect, we measured anxiety and depression-related behaviors in mice after spinal nerve ligation using classical behavioral tests. METHODS After unilateral… CONTINUE READING

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