Experimental myositis ossificans: cartilage and bone formation in muscle in response to a diffusible bone matrix-derived morphogen.

@article{Urist1978ExperimentalMO,
  title={Experimental myositis ossificans: cartilage and bone formation in muscle in response to a diffusible bone matrix-derived morphogen.},
  author={Marshall R. Urist and Masao Nakagawa and Norihito Nakata and Hiroshi Nogami},
  journal={Archives of pathology & laboratory medicine},
  year={1978},
  volume={102 6},
  pages={
          312-6
        }
}
Bone matrix gelatin, prepared by chemical extraction of soluble noncollagenous proteins, was half digested with a chromatographically purified collagenase. The residue was placed on one side and autologous muscle on the other side of cellulose acetate membranes in diffusion chambers and tissue cultures. In this avascular system, the muscle septa connective tissue proliferated and differentiated into cartilage. Muscle tissue cultured in media conditioned with matrix residues and then transferred… CONTINUE READING

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