Experimental murine paracoccidiodomycosis induced by the inhalation of conidia.

  title={Experimental murine paracoccidiodomycosis induced by the inhalation of conidia.},
  author={Juan G Mcewen and V{\'i}ctor Bedoya and Mercedes M. Patino and M Ester Salazar and {\'A}ngela Restrepo},
  journal={Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology},
  volume={25 3},
Adult BALB/c mice of both sexes were infected intranasally with 10(6) viable P. brasiliensis conidia. Animals were sacrificed at intervals up to 6 months and studied by histopathology and organ cultures. At the time of challenge lung sections showed that instilled conidia had reached the alveoli; at 12 h such conidia were transforming into yeast cells, with multiple buds appearing by 18 h. Initially, the cellular infiltrate was composed of polymorphonuclear leukocytes; 6 days later, lymphocytes… CONTINUE READING

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