Experimental models of Parkinson's disease

  title={Experimental models of Parkinson's disease},
  author={Myron Flint Beal},
  journal={Nature Reviews Neuroscience},
Research into the pathogenesis of Parkinson's disease has been rapidly advanced by the development of animal models. Initial models were developed by using toxins that specifically targeted dopamine neurons, the most successful of which used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a toxin that causes parkinsonism in man. More recently, the identification of α-synuclein mutations as a rare cause of Parkinson's disease has led to the development of α-synuclein transgenic mice and Drosophila… CONTINUE READING
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