Experimental model of invasion and metastasis by orthotopic transplantation of oral squamous and adenoid cystic carcinomas into the tongue of nude mice.

@article{Umeda2001ExperimentalMO,
  title={Experimental model of invasion and metastasis by orthotopic transplantation of oral squamous and adenoid cystic carcinomas into the tongue of nude mice.},
  author={Masahiro Umeda and Satoshi Yokoo and Takahide Komori and Naruki Nishimatsu and Yasuyuki Shibuya and Masako Fujioka},
  journal={The British journal of oral & maxillofacial surgery},
  year={2001},
  volume={39 5},
  pages={376-80}
}
Three squamous cell carcinoma (SCC) cell lines established from oral cancer, seven specimens of SCC and three of adenoid cystic carcinomas taken from the oral cavity during operations were transplanted into the tongues of nude mice. Metastases to the regional lymph nodes and the lungs were examined histologically. We were able to transplant every cell line or specimen of tissue into the tongue of nude mice, and found that cancer transplanted in the tongue invaded diffusely to the surrounding… CONTINUE READING

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