Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na+/K+ ATPase expression and activity in kidney proximal tubule cells.

@article{Sampaio2018ExperimentalIM,
  title={Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na+/K+ ATPase expression and activity in kidney proximal tubule cells.},
  author={Luzia da Silva Sampaio and Fabio Arturo Iannotti and Luciana Veneziani and Rosa T Borelli-T{\^o}rres and Fabrizia De Maio and Fabiana Piscitelli and Ricardo A. M. Reis and Vincenzo Di Marzo and M Einicker-Lamas},
  journal={Biochemical pharmacology},
  year={2018},
  volume={154},
  pages={
          482-491
        }
}
LLC-PK1 cells, an immortalized epithelial cell line derived from pig renal proximal tubules, express all the major players of the endocannabinoid system (ECS) such as CB1, CB2 and TRPV1 receptors, as well as the main enzymes involved in the biosynthesis and degradation of the major endocannabinoids named 2-arachidonoylglycerol, 2-AG and anandamide, AEA. Here we investigated whether the damages caused by ischemic insults either in vitro using LLC-PK1 cells exposed to antimycin A (an inductor of… CONTINUE READING
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