Experimental inhibition of peroxisomal beta-oxidation in rats: influence on brain myelination.

@article{Branden1990ExperimentalIO,
  title={Experimental inhibition of peroxisomal beta-oxidation in rats: influence on brain myelination.},
  author={Christiane van den Branden and Joanna Leeman and Georges A. A. Dacremont and R Collumbien and Frank Roels},
  journal={Glia},
  year={1990},
  volume={3 6},
  pages={458-63}
}
Oral administration of thioridazine, an inhibitor of peroxisomal beta-oxidation, to normal rats from weaning till day 60 causes a small increase of the very long chain fatty acid C26 in brain lipids. Myelination in the brain is decreased. In the genu of the corpus callosum the ratio of non-myelinated/myelinated axons is increased. In the commissura anterior the myelin sheaths of the axons are significantly thinner in treated than in control animals. Undernourishment caused by the drug is… CONTINUE READING