Experimental infection of the laboratory rat with the hepatitis E virus.

  title={Experimental infection of the laboratory rat with the hepatitis E virus.},
  author={Yaowapa Maneerat and Edward T. Clayson and Khin Saw Aye Myint and Geoffrey D. Young and Bruce L. Innis},
  journal={Journal of medical virology},
  volume={48 2},
To confirm an earlier report that laboratory rats are susceptible to infection with the hepatitis E virus (HEV), we inoculated 27 Wistar rats intravenously with a suspension of a human stool known to contain infectious HEV. Stool, sera, and various tissues were collected from three rats each on days 0 (preinoculation) and 4, 7, 11, 14, 18, 21, 25, 28, and 35 postinoculation. Stool and sera specimens were examined by reverse transcription-polymerase chain reaction for the presence of HEV genomic… CONTINUE READING


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