Experimental infection of inbred mice with herpes simplex virus. II. Interferon production and activation of natural killer cells in the peritoneal exudate.

@article{Engler1981ExperimentalIO,
  title={Experimental infection of inbred mice with herpes simplex virus. II. Interferon production and activation of natural killer cells in the peritoneal exudate.},
  author={H. Engler and Rainer Zawatzky and Andrei Goldbach and Claus H. Schr{\"o}der and Connie Weyand and G{\"u}nther H{\"a}mmerling and Holger Kirchner},
  journal={The Journal of general virology},
  year={1981},
  volume={55 Pt 1},
  pages={
          25-30
        }
}
The peritoneal exudate cells (PEC) represent the first line of defence against the virus in the mouse model of intraperitoneal (i.p.) infection with herpes simplex virus (HSV). We have therefore studied interferon production and activation of natural killer (NK) cells in vitro in PEC of HSV-injected mice. Injection of HSV caused a marked increase in NK cell activity, as reported by others. PEC from HSV-injected mice also produced high titres of interferon. This observation may be important… 
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Herpes simplex virus type 1-induced interferon production and activation of natural killer cells in mice.
TLDR
Cultures of peritoneal exudate cells (PEC) of non-immune C57BL/6 mice reacted to infectious herpes simplex virus type 1 (HSV), but not to non-infectious virions, suggesting that in PEC the cells which produced interferon were of the macrophage lineage.
Herpes simplex virus - induced interferon production and activation of natural killer cells in SM/J mice. Relation to antiviral resistance.
INTERFERON, NATURAL KILLER CELLS AND GENETICALLY DETERMINED RESISTANCE OF MICE AGAINST HERPES SIMPLEX VIRUS
Activation of natural killer cells and induction of interferon after injection of mouse hepatitis virus type 3 in mice
TLDR
The data suggest that, in contrast to the situation observed with certain herpesviruses, interferon and NK cells may not be of overwhelming importance in the defense of mice against MHV3.
Experimental infection of inbred mice with herpes simplex virus
TLDR
Inbred mouse strains differ in susceptibility to infection with herpes simplex virus type 1 or type 2 (HSV-1, HSV-2), and early (2 to 4 hours) interferon production was correlated to resistance.
Natural Resistance to Herpes Simplex Virus Infections: The Macrophage-Interferon Axis
TLDR
Clinical observations suggest that during recurrent HSV infection IFN γ is secreted locally by activated T lymphocytes and may synergize with IFN α/β in the antiviral activity against HSV.
Studies on the interrelation of resistance and immunity in a mouse model system of herpes-simplex type 2 infection.
Recovery from lethal herpes simplex virus type 1 infection is mediated by cytotoxic T lymphocytes
TLDR
It is demonstrated that Lyt 2-positive cells with cytotoxic activity generated by in vitro immunization can mediate recovery from lethal HSV infection, whereas, under the conditions chosen, Lyt 1- positive cells were unable tomediate recovery.
Experimental Infection of Inbred Mice with Herpes Simplex Virus. V. Investigations with a Virus Strain Non-lethal after Peripheral Infection
TLDR
Experiments with silica-treated mice, and with homozygous nude mice, suggested that the observed restriction in virus transfer is independent of T-cell and macrophage functions, suggesting that age-dependent defence mechanisms are of relevance in the restriction of peripheral infection by HSV-1 ANG in adult mice.
Experimental infection of inbred mice with herpes simplex virus. III. Comparison between newborn and adult C57BL/6 mice.
TLDR
Newborn C57BL/6 mice, in contrast to adult mice, did not develop natural killer cell activity in the peritoneal cavity 24 h after i.p. injection of HSV-1, and showed only minimal titres of interferon in thePeritoneal fluid after 4 h.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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