Experimental infection of cynomolgus macaques with Ebola-Reston filoviruses from the 1989-1990 U.S. epizootic.

@article{Jahrling1996ExperimentalIO,
  title={Experimental infection of cynomolgus macaques with Ebola-Reston filoviruses from the 1989-1990 U.S. epizootic.},
  author={P. Jahrling and T. Geisbert and N. Jaax and M. Hanes and T. Ksiazek and C. Peters},
  journal={Archives of virology. Supplementum},
  year={1996},
  volume={11},
  pages={
          115-34
        }
}
This study describes the pathogenesis of the Ebola-Reston (EBO-R) subtype of Ebola virus for experimentally infected cynomolgus monkeys. The disease course of EBO-R in macaques was very similar to human disease and to experimental diseases in macaques following EBO-Zaire and EBO-Sudan infections. Cynomolgus monkeys infected with EBO-R in this experiment developed anorexia, occasional nasal discharge, and splenomegaly, petechial facial hemorrhages and severe subcutaneous hemorrhages in… Expand
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